Chemical synapse.

  • Voltage-gated Ca^2+ channels in the presynaptic membrane open in response to an action potential.
  • Ca^2+ ions flow in.
  • Synaptic vesicles fuse with presynaptic membrane of the synaptic terminal, releasing neurotransmitters.
  • Neurotransmitters diffuse across synaptic cleft and bind to ligand-gated channels in the postsynaptic membrane.
  • Ions flow in and generate a postsynaptic potential.
  • Neurotransmitters release from channels, which close.

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