Hormonal control of spermatogenesis.

Gonadotropin-releasing hormone (GnRH) from the hypothalamus stimulates the anterior pituitary to secrete two hormones.


  • Follicle-Stimulating Hormone (FSH) acts on Sertoli cells, which nourish developing sperm. Sertoli cells also secrete Inhibin, which reduces FSH secretion by negative feedback.
  • Luteinizing Hormone (LH) acts on Leydig cells, which produce androgens, chiefly testosterone. Testosterone regulates production of the brain hormones by negative feedback.